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Clinical Chemistry | Oxford Academic

Clinical Chemistry is a high-impact peer-reviewed publication, ranked as the most cited journal in the fields of clinical chemistry,

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Instruments, recherche, réactifs et services pour les laboratoires des Sciences de la vie permettant de réaliser de nouvelles découvertes dans le cadre du développement et de la recherche en biologie.
Process in which adding a solute to a solvent decreases the freezing point of the solvent. Freezing-point depression is a drop in the minimum temperature at which a substance freezes, caused when a smaller amount of another, non-volatile substance is added. Examples include adding salt into water (used in ice cream makers and for de-icing roads), alcohol in water, ethylene or propylene glycol in water (used in antifreeze in cars), adding copper to molten silver (used to make solder that flows at a lower temperature than the silver pieces being joined), or the mixing of two solids such as impurities into a finely powdered drug. In all cases, the substance added/present in smaller amounts is considered the solute, while the original substance present in larger quantity is thought of as the solvent. The resulting liquid solution or solid-solid mixture has a lower freezing point than the pure solvent or solid because the chemical potential of the solvent in the mixture is lower than that of the pure solvent, the difference between the two being proportional to the natural logarithm of the mole fraction. In a similar manner, the chemical potential of the vapor above the solution is lower than that above a pure solvent, which results in boiling-point elevation.

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