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Antiguo servicio para acortar URLs desde elpais.com Chemical compound. The cortistatins are a group of steroidal alkaloids first isolated in 2006 from the marine sponge Corticium simplex. The cortistatins were first discovered in a search for naturally occurring compounds that inhibit proliferation of human umbilical vein endothelial cells (HUVECs), with cortistatin A being the most potent compound in the class.The Shair group at Harvard along with collaborators have shown that cortistatin A is a highly potent and selective inhibitor of CDK8 and CDK19, the kinases that associate with Mediator complex. Out of 386 kinases evaluated, cortistatin A only inhibited CDK8 and CDK19, revealing that it is among the most selective kinase inhibitors. It was also shown that cortistatin A potently inhibits growth of acute myeloid leukemia cells and AML in two in vivo mouse models. Identification of dominant drug-resistant alleles of CDK8 and CDK19 demonstrate that these kinases mediate the activity of cortistatin A in AML cells. https://en.wikipedia.org/wiki/Cortistatins
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S.id is a free platform that provides easy and comprehensive tools to quickly create a microsite for bio link and a free link shortening service for creating short and easy-to-remember links that can be used to promote your website or product. Communications and journalism school at Syracuse University. The S.I. Newhouse School of Public Communications, commonly known as Newhouse School, is the communications and journalism school of Syracuse University in Syracuse, NY. It has programs in print and broadcast journalism; music business; graphic design; advertising; public relations; and television, radio and film. The school was named after publishing magnate Samuel Irving Newhouse Sr., founder of Advance Publications, who provided the founding gift in 1964.Mark J. Lodato has been the dean of the Newhouse School since July 2020. The school includes about 80 full-time faculty members and about 50 adjunct instructors. Enrollment includes approximately 2,000 undergraduate students, 180 residential master’s degree students, 200 online master's degree students, and 15 doctoral degree candidates as of 2022. Undergraduate admissions are highly selective.

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