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Foundations for routine 3D X-ray histology (XRH) | µ-VIS: Multidisciplinary, Multiscale, Microtomographic Volume Imaging | University of Southampton

Setting the foundations for X-ray micro-computed tomography workflow for non-destructive 3D X-ray histology (XRH): X-ray imaging by micro-computed tomography (uCT) is a key technique in the rapidly developing field of 3D microscopy. Until recently, 3D imaging of wax-embedded histological tissues was beyond the reach of microCT. However, we have shown that it is possible to non-invasively generate microstructural detail from standard tissue blocks and have provided evidence that this can overturn misconceptions of disease development when just relying on 2D assessment. Building on our previous Wellcome Trust Pathfinder funding, we will develop a research capability, emphasising X-ray hardware performance and flexibility, large-scale computing resource/tools and validation with 2D histology.

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Topics: 3d microscopy, 3d x-ray histology, biomedical imaging unit, biu, foundations for routine 3d x-ray histology (xrh), histology, micro-computed tomography, microtomographic volume imaging, multidisciplinary, multiscale, university of southampton, x-ray, μct, μ-vis x-ray imaging centre

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